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TERRA Incognita at chromosome ends
Author(s) -
Coulon Stéphane,
Géli Vincent
Publication year - 2016
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201642583
Subject(s) - telomere , telomerase , biology , protein subunit , schizosaccharomyces pombe , rna , polyadenylation , microbiology and biotechnology , genetics , schizosaccharomyces , dna , gene , saccharomyces cerevisiae
Telomeres are transcribed in long noncoding RNA named TERRA . Although TERRA functions have been extensively investigated, the role of TERRA in telomerase recruitment and regulation is still elusive. In this issue of EMBO Reports , Moravec et al report in Schizosaccharomyces pombe that telomere shortening induces the expression of TERRA [1][Moravec M, 2016]. They show that polyadenylated TERRA molecules specifically associate with the telomerase catalytic subunit and stimulate telomerase‐mediated elongation of the telomere from which the TERRA molecules originate. Strikingly, their results indicate that shaping the 3′ end of telomere transcripts controls telomerase activity.