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HUWE 1 comes to the rescue at stalled replication forks
Author(s) -
Coleman Kate E,
Huang Tony T
Publication year - 2016
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201642551
Subject(s) - ubiquitin ligase , biology , replication (statistics) , microbiology and biotechnology , dna replication , ubiquitin , function (biology) , pre replication complex , origin recognition complex , genetics , eukaryotic dna replication , computational biology , dna , gene , virology
HUWE 1 is a multi‐faceted E3 ubiquitin ligase of the HECT family with many confirmed substrates, but mechanistic understanding of its functional roles in signaling pathways remains limited. In this issue of EMBO Reports , Choe et al demonstrate a novel function for HUWE 1 in promoting DNA damage tolerance mechanisms to bypass DNA lesions during replication stress, thereby preserving genome stability. The authors connect this role for HUWE 1 with its function in maintaining H2 AX monoubiquitination levels for efficient signaling at stalled replication forks [1][Choe KN, 2016]. Thus, this work highlights HUWE 1 as a novel player in the replication stress response and prompts further investigation of its regulation during replication and other cellular processes.