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CD 1d‐mediated activation of group 3 innate lymphoid cells drives IL ‐22 production
Author(s) -
Saez de Guinoa Julia,
Jimeno Rebeca,
Farhadi Nazanin,
Jervis Peter J,
Cox Liam R,
Besra Gurdyal S,
Barral Patricia
Publication year - 2017
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201642412
Subject(s) - innate lymphoid cell , cd1d , biology , immune system , microbiology and biotechnology , innate immune system , immunology , antigen presentation , t cell , natural killer t cell
Innate lymphoid cells ( ILC s) are a heterogeneous family of immune cells that play a critical role in a variety of immune processes including host defence against infection, wound healing and tissue repair. Whether these cells are involved in lipid‐dependent immunity remains unexplored. Here we show that murine ILC s from a variety of tissues express the lipid‐presenting molecule CD 1d, with group 3 ILC s ( ILC 3s) showing the highest level of expression. Within the ILC 3 family, natural cytotoxicity triggering receptor ( NCR ) − CCR 6 + cells displayed the highest levels of CD 1d. Expression of CD 1d on ILC s is functionally relevant as ILC 3s can acquire lipids in vitro and in vivo and load lipids on CD 1d to mediate presentation to the T‐cell receptor of invariant natural killer T ( iNKT ) cells. Conversely, engagement of CD 1d in vitro and administration of lipid antigen in vivo induce ILC 3 activation and production of IL ‐22. Taken together, our data expose a previously unappreciated role for ILC s in CD 1d‐mediated immunity, which can modulate tissue homeostasis and inflammatory responses.