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Lnc RNA ‐ MIF , a c‐Myc‐activated long non‐coding RNA , suppresses glycolysis by promoting Fbxw7‐mediated c‐Myc degradation
Author(s) -
Zhang Pengfei,
Cao Limian,
Fan Pingsheng,
Mei Yide,
Wu Mian
Publication year - 2016
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201642067
Subject(s) - rna , rna binding protein , microbiology and biotechnology , long non coding rna , ubiquitin ligase , chemistry , biology , biochemistry , gene , ubiquitin
The c‐Myc proto‐oncogene is activated in more than half of all human cancers. However, the precise regulation of c‐Myc protein stability is unknown. Here, we show that the lnc RNA ‐ MIF (c‐Myc inhibitory factor), a c‐Myc‐induced long non‐coding RNA , is a competing endogenous RNA for miR‐586 and attenuates the inhibitory effect of miR‐586 on Fbxw7, an E3 ligase for c‐Myc, leading to increased Fbxw7 expression and subsequent c‐Myc degradation. Our data reveal the existence of a feedback loop between c‐Myc and lnc RNA ‐ MIF , through which c‐Myc protein stability is finely controlled. Additionally, we show that the lnc RNA ‐ MIF inhibits aerobic glycolysis and tumorigenesis by suppressing c‐Myc and miR‐586.