A new approach to toxin neutralization in   S taphylococcus aureus  therapy | Zendy

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A new approach to toxin neutralization in S taphylococcus aureus therapy

Author(s) -

Parker Dane,

Prince Alice

Publication year - 2016

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.15252/embr.201642015

Subject(s) - staphylococcus aureus , leukocidin , panton–valentine leukocidin , columbia university , medicine , methicillin resistant staphylococcus aureus , biology , genetics , media studies , bacteria , sociology

Staphylococcus aureus is a significant human pathogen responsible for a range of diseases including pneumonia, sepsis, skin, and soft tissue infections. An important component of its success as a human pathogen is the production of a large array of virulence factors including several toxins. In this issue of EMBO Reports , Reyes‐Robles and colleagues [1][Reyes‐Robles T, 2016] identify a glycine‐rich motif shared by bicomponent leukocidins. When this motif is deleted, the altered toxin exerts dominant‐negative effects that neutralize leukocidin function and thus represents a potentially novel avenue for S. aureus therapy.

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