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Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes
Author(s) -
Gómez Rocío,
FelipeMeditalia,
RuizTorres Miguel,
Berenguer Inés,
Viera Alberto,
Pérez Sara,
Barbero José Luis,
Llano Elena,
Fukuda Tomoyuki,
Alsheimer Manfred,
Pendás Alberto M,
Losada Ana,
Suja José A
Publication year - 2016
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201541060
Subject(s) - cohesin , synaptonemal complex , meiosis , biology , microbiology and biotechnology , anaphase , prophase , centromere , mitosis , homologous chromosome , chromosome segregation , genetics , chromosome , gene
The distribution and regulation of the cohesin complexes have been extensively studied during mitosis. However, the dynamics of their different regulators in vertebrate meiosis is largely unknown. In this work, we have analyzed the distribution of the regulatory factor Sororin during male mouse meiosis. Sororin is detected at the central region of the synaptonemal complex during prophase I, in contrast with the previously reported localization of other cohesin components in the lateral elements. This localization of Sororin depends on the transverse filaments protein SYCP 1, but not on meiosis‐specific cohesin subunits REC 8 and SMC 1β. By late prophase I, Sororin accumulates at centromeres and remains there up to anaphase II . The phosphatase activity of PP 2A seems to be required for this accumulation. We hypothesize that Sororin function at the central region of the synaptonemal complex could be independent on meiotic cohesin complexes. In addition, we suggest that Sororin participates in the regulation of centromeric cohesion during meiosis in collaboration with SGO 2‐ PP 2A.