Reduced C/ EBP β‐ LIP translation improves metabolic health

Inactivation of target of rapamycin complex 1 ( TORC 1) signaling is considered important for the beneficial effects of caloric restriction ( CR ) on metabolism and health span. It is however not fully elucidated which cellular processes downstream of TORC 1 are the main regulators of metabolic health. In this issue of EMBO Reports, Zidek et al [1][Zidek LM, 2015] describe that inhibition of mammalian TORC 1 ( mTORC 1) leads to decreased translation of CCAAT /enhancer‐binding protein β (C/ EBP β)‐liver inhibitory protein ( LIP ). Moreover, loss of C/ EBP β‐ LIP in mice improves metabolic health, similar to the effects of CR . Zidek et al [1][Zidek LM, 2015] thus report that reduced C/ EBP β‐ LIP translation is a novel mTORC 1‐regulated process that could play a major role in mediating the beneficial metabolic effects of caloric restriction.