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Reduced C/ EBP β‐ LIP translation improves metabolic health
Author(s) -
Albert Verena,
Hall Michael N
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201540757
Subject(s) - eukaryotic translation , translation (biology) , chemistry , biochemistry , messenger rna , gene
Inactivation of target of rapamycin complex 1 ( TORC 1) signaling is considered important for the beneficial effects of caloric restriction ( CR ) on metabolism and health span. It is however not fully elucidated which cellular processes downstream of TORC 1 are the main regulators of metabolic health. In this issue of EMBO Reports, Zidek et al [1][Zidek LM, 2015] describe that inhibition of mammalian TORC 1 ( mTORC 1) leads to decreased translation of CCAAT /enhancer‐binding protein β (C/ EBP β)‐liver inhibitory protein ( LIP ). Moreover, loss of C/ EBP β‐ LIP in mice improves metabolic health, similar to the effects of CR . Zidek et al [1][Zidek LM, 2015] thus report that reduced C/ EBP β‐ LIP translation is a novel mTORC 1‐regulated process that could play a major role in mediating the beneficial metabolic effects of caloric restriction.