Another face of  RIPK 1 | Zendy

Green Douglas R | Zendy

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Another face of RIPK 1

Author(s) -

Green Douglas R

Publication year - 2015

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.15252/embr.201540470

Subject(s) - ripk1 , necroptosis , microbiology and biotechnology , phosphorylation , context (archaeology) , autophagy , biology , signal transduction , transcription factor , kinase , mapk/erk pathway , fadd , apoptosis , programmed cell death , genetics , gene , caspase , paleontology

Receptor‐interacting protein kinase‐1 ( RIPK 1) sits at a signaling node controlling a number of functional pathways. These include both positive and negative control of apoptosis and necroptosis (a form of regulated necrosis). In this issue of EMBO Reports , Yonekawa and colleagues describe another function for RIPK 1, the inhibition of autophagy via ERK ‐mediated phosphorylation of the transcription factor, TFEB [1][Yonekawa T, 2015]. Their findings are considered in the context of RIPK 1 signaling, and how it is engaged.

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