Premium
Another face of RIPK 1
Author(s) -
Green Douglas R
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201540470
Subject(s) - ripk1 , necroptosis , microbiology and biotechnology , phosphorylation , context (archaeology) , autophagy , biology , signal transduction , transcription factor , kinase , mapk/erk pathway , fadd , apoptosis , programmed cell death , genetics , gene , caspase , paleontology
Receptor‐interacting protein kinase‐1 ( RIPK 1) sits at a signaling node controlling a number of functional pathways. These include both positive and negative control of apoptosis and necroptosis (a form of regulated necrosis). In this issue of EMBO Reports , Yonekawa and colleagues describe another function for RIPK 1, the inhibition of autophagy via ERK ‐mediated phosphorylation of the transcription factor, TFEB [1][Yonekawa T, 2015]. Their findings are considered in the context of RIPK 1 signaling, and how it is engaged.