JAK / STAT  signaling in   D rosophila  muscles controls the cellular immune response against parasitoid infection | Zendy

Yang Hairu | Zendy; Kronhamn Jesper | Zendy; Ekström JensOla | Zendy; Korkut Gül Gizem | Zendy; Hultmark Dan | Zendy

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JAK / STAT signaling in D rosophila muscles controls the cellular immune response against parasitoid infection

Author(s) -

Yang Hairu,

Kronhamn Jesper,

Ekström JensOla,

Korkut Gül Gizem,

Hultmark Dan

Publication year - 2015

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.15252/embr.201540277

Subject(s) - stat , immune system , microbiology and biotechnology , signal transduction , biology , immunology , stat3

The role of JAK / STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK / STAT signaling in somatic muscles of the D rosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3 , but not the related os ( upd1 ) gene, reduced the cellular immune response, and suppression of the JAK / STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK / STAT signaling in muscles participates in a systemic immune defense against wasp infection.

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