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JAK / STAT signaling in D rosophila muscles controls the cellular immune response against parasitoid infection
Author(s) -
Yang Hairu,
Kronhamn Jesper,
Ekström JensOla,
Korkut Gül Gizem,
Hultmark Dan
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201540277
Subject(s) - stat , immune system , microbiology and biotechnology , parasitoid , biology , signal transduction , chemistry , host (biology) , immunology , ecology , stat3
The role of JAK / STAT signaling in the cellular immune response of Drosophila is not well understood. Here, we show that parasitoid wasp infection activates JAK / STAT signaling in somatic muscles of the D rosophila larva, triggered by secretion of the cytokines Upd2 and Upd3 from circulating hemocytes. Deletion of upd2 or upd3 , but not the related os ( upd1 ) gene, reduced the cellular immune response, and suppression of the JAK / STAT pathway in muscle cells reduced the encapsulation of wasp eggs and the number of circulating lamellocyte effector cells. These results suggest that JAK / STAT signaling in muscles participates in a systemic immune defense against wasp infection.