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Catching the adaptor— WDFY 1, a new player in the TLR – TRIF pathway
Author(s) -
Nandakumar Ramya,
Paludan Søren R
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201540145
Subject(s) - trif , signal transducing adaptor protein , microbiology and biotechnology , signal transduction , chemistry , receptor , innate immune system , biology , biochemistry , toll like receptor
The innate immune system detects microbes and abnormal self through pattern recognition receptors ( PRR s), which detect molecules that are either specific for microbes (such as lipopolysaccharide), present in much higher concentrations during infection (such as double‐stranded RNA ), or present in aberrant locations (such as cytosolic DNA ) [1][Kawai T, 2011]. The Toll‐like receptors ( TLR s) are the best‐described set of PRR s. TLR s are membrane‐bound receptors localized on the plasma membrane and in endosomes, the ligand‐binding regions of which face the extracellular environment and the endosomal lumen, respectively [1][Kawai T, 2011]. In this issue of EMBO Reports , Hu and colleagues report that WD ‐repeat and FYVE ‐domain‐containing protein 1 ( WDFY 1) recruits the signaling adaptor TRIF to TLR 3 and TLR 4, thereby potentiating signaling from these PRR s (Fig [Figure 1. WDFY1, a new player in the TLR‐TRIF pathway]); [2][Hu YH, 2015].