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The biology of IQGAP proteins: beyond the cytoskeleton
Author(s) -
Hedman Andrew C,
Smith Jessica M,
Sacks David B
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439834
Subject(s) - microbiology and biotechnology , cytoskeleton , biology , iqgap1 , cytokinesis , function (biology) , intracellular , model organism , scaffold protein , signal transduction , cell , genetics , cell division , gene
IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP 1, IQGAP 2, and IQGAP 3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio‐vascular system, pancreas, and lung. The functions of IQGAP s can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAP s represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAP s, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAP s to physiology at the organism level.