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Closing the MCM cycle at replication termination sites
Author(s) -
Lengronne Armelle,
Pasero Philippe
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439774
Subject(s) - origin recognition complex , minichromosome maintenance , dna replication , helicase , control of chromosome duplication , eukaryotic dna replication , microbiology and biotechnology , pre replication complex , biology , genetics , origin of replication , chromatin , replication factor c , dna , gene , rna
The initiation of eukaryotic DNA replication is a highly regulated process conserved from yeast to human. The past decade has seen significant advances in understanding how the CMG (Cdc45‐ MCM ‐ GINS ) replicative helicase is loaded onto DNA . However, very little was known on how this complex is removed from chromatin at the end of S phase. Two papers in a recent issue of Science [1][Maric M, 2014][2][Moreno SP, 2014] show that in yeast and in Xenopus , the CMG complex is unloaded at replication termination sites by an active mechanism involving the polyubiquitylation of Mcm7.