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Micro‐ RNA s meet epigenetics to make for better brains
Author(s) -
Noack Florian,
Calegari Federico
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439682
Subject(s) - neurogenesis , epigenetics , dna methylation , biology , rna , neural stem cell , non coding rna , cell cycle , microbiology and biotechnology , chromatin , rna methylation , methylation , genetics , dna , stem cell , methyltransferase , cell , gene expression , gene
Recent studies have highlighted the importance of regulatory non‐coding RNA s and epigenetics in controlling the differentiation of somatic stem cells. Two major pathways characterize these fields: micro‐ RNA s (mi RNA s) and DNA methylation. In this issue of EMBO Reports , Lv et al show that during mammalian corticogenesis, miR‐15b inhibits cytosine demethylation by targeting T et3, a key methylcytosine dioxygenase. This leads to the epigenetic downregulation of cyclin D 1. As a result, cell cycle and differentiation of neural progenitors are altered, promoting their switch to neurogenesis. Hence, Lv et al elegantly bring together mi RNA s and DNA methylation in the cell cycle control of neural progenitors and neurogenesis.