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Wnt‐mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation
Author(s) -
Stolz Ailine,
Neufeld Kim,
Ertych Norman,
Bastians Holger
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439410
Subject(s) - wnt signaling pathway , microbiology and biotechnology , mitosis , biology , cell cycle , chromosome segregation , spindle apparatus , tcf4 , microtubule , cell division , signal transduction , genetics , cell , transcription factor , chromosome , gene , enhancer
Wnt signaling stimulates cell proliferation by promoting the G1/S transition of the cell cycle through β‐catenin/ TCF 4‐mediated gene transcription. However, Wnt signaling peaks in mitosis and contributes to the stabilization of proteins other than β‐catenin, a pathway recently introduced as Wnt‐dependent stabilization of proteins (Wnt/ STOP ). Here, we show that Wnt/ STOP regulated by basal Wnt signaling during a normal cell cycle is required for proper spindle microtubule assembly and for faithful chromosome segregation during mitosis. Consequently, inhibition of basal Wnt signaling results in increased microtubule assembly rates, abnormal mitotic spindle formation and the induction of aneuploidy in human somatic cells.