Premium
Positive feedback regulation of type I interferon by the interferon‐stimulated gene STING
Author(s) -
Ma Feng,
Li Bing,
Yu Yongxin,
Iyer Shankar S,
Sun Mingyu,
Cheng Genhong
Publication year - 2015
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439366
Subject(s) - interferon , sting , interferon type i , stimulator of interferon genes , gene , biology , genetics , microbiology and biotechnology , innate immune system , receptor , engineering , aerospace engineering
Stimulator of interferon genes ( STING ) is an important regulator of the innate immune response to cytoplasmic DNA . However, regulation of STING itself is largely unknown. Here, we show that STING transcription is induced by innate immune activators, such as cyclic dinucleotides ( CDN s), through an IFNAR 1‐ and STAT 1‐dependent pathway. We also identify a STAT 1 binding site in the STING promoter that contributes to the activation of STING transcription. Furthermore, we show that induction of STING mediates the positive feedback regulation of CDN ‐triggered IFN ‐I. Thus, our study demonstrates that STING is an interferon‐stimulated gene ( ISG ) and its induction is crucial for the IFN ‐I positive feedback loop.