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p38 links RAS to GATA 2
Author(s) -
Baumgartner Christian,
Baccarini Manuela
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439309
Subject(s) - transcription factor , gata transcription factor , microbiology and biotechnology , biology , transformation (genetics) , computational biology , genetics , gene , gene expression , promoter
More than 30% of all human cancers contain activating mutations of the small G‐protein RAS . As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS ‐driven transformation [1][Stephen AG, 2014]. Recent studies have indicated that the transcription factor GATA 2 is one of these partners in crime, but a mechanistic link between RAS and GATA 2 had not been identified [2][Kumar MS, 2012]. A paper in this issue of EMBO reports closes this gap showing that GATA 2 can be activated by p38 in RAS‐transformed cells [3][Katsumura KR, 2014].