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HDAC 4 promotes P ax7‐dependent satellite cell activation and muscle regeneration
Author(s) -
Choi MoonChang,
Ryu Soyoung,
Hao Rui,
Wang Bin,
Kapur Meghan,
Fan ChenMing,
Yao TsoPang
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201439195
Subject(s) - adipogenesis , microbiology and biotechnology , regulator , regeneration (biology) , cell growth , biology , adipose tissue , chemistry , gene , biochemistry , mesenchymal stem cell
During muscle regeneration, the transcription factor P ax7 stimulates the differentiation of satellite cells ( SC s) toward the muscle lineage but restricts adipogenesis. Here, we identify HDAC 4 as a regulator of P ax7‐dependent muscle regeneration. In HDAC 4‐deficient SC s, the expression of P ax7 and its target genes is reduced. We identify HDAC 4‐regulated Lix1 as a P ax7 target gene required for SC proliferation. HDAC 4 inactivation leads to defective SC proliferation, muscle regeneration, and aberrant lipid accumulation. Further, expression of the brown adipose master regulator P rdm16 and its inhibitory micro RNA ‐133 are also deregulated. Thus, HDAC 4 is a novel regulator of P ax7‐dependent SC proliferation and potentially fate determination in regenerating muscle.