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Epithelial–stromal interaction via N otch signaling is essential for the full maturation of gut‐associated lymphoid tissues
Author(s) -
Obata Yuuki,
Kimura Shunsuke,
Nakato Gaku,
Iizuka Keito,
Miyagawa Yurika,
Nakamura Yutaka,
Furusawa Yukihiro,
Sugiyama Machiko,
Suzuki Keiichiro,
Ebisawa Masashi,
Fujimura Yumiko,
Yoshida Hisahiro,
Iwanaga Toshihiko,
Hase Koji,
Ohno Hiroshi
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201438942
Subject(s) - notch signaling pathway , stromal cell , microbiology and biotechnology , biology , epithelium , transcription factor , signal transduction , intestinal epithelium , cellular differentiation , cell signaling , lymphatic system , immunology , gene , genetics , cancer research
Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut‐associated lymphoid tissue ( GALT ), stromal cells located beneath the follicle‐associated epithelium ( FAE ) abundantly express the Notch ligand delta‐like 1 (Dll1). Here, we show that mice lacking Rbpj —a gene encoding a transcription factor implicated in Notch signaling—in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down‐regulation of CCL 20 in FAE . These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE .