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Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor A tg19
Author(s) -
Pfaffenwimmer Thaddaeus,
Reiter Wolfgang,
Brach Thorsten,
Nogellova Veronika,
Papinski Daniel,
Schuschnig Martina,
Abert Christine,
Ammerer Gustav,
Martens Sascha,
Kraft Claudine
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201438932
Subject(s) - phosphorylation , microbiology and biotechnology , autophagy , kinase , receptor , chemistry , biology , biochemistry , apoptosis
Autophagy is the major pathway for the delivery of cytoplasmic material to the vacuole or lysosome. Selective autophagy is mediated by cargo receptors, which link the cargo to the scaffold protein Atg11 and to Atg8 family proteins on the forming autophagosomal membrane. We show that the essential kinase Hrr25 activates the cargo receptor Atg19 by phosphorylation, which is required to link cargo to the Atg11 scaffold, allowing selective autophagy to proceed. We also find that the Atg34 cargo receptor is regulated in a similar manner, suggesting a conserved mechanism.