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Yeast X‐chromosome‐associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts
Author(s) -
Anver Shajahan,
Roguev Assen,
Zofall Martin,
Krogan Nevan J,
Grewal Shiv I S,
Harmer Stacey L
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201438902
Subject(s) - genetics , biology , yeast , chromosome , saccharomyces cerevisiae , gene
Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome‐wide genetic screen, we implicate a novel protein called X‐chromosome‐associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin‐associated protein acting in a similar manner as the histone variant H 2 A . Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome. Xap5 is highly conserved across eukaryotes, and a plant homolog rescues xap5 mutant yeast. We propose that X ap5 likely functions as a chromatin regulator in diverse organisms.