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Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human
Author(s) -
Kushwah Rahul,
Guezguez Borhane,
Lee Jung Bok,
Hopkins Claudia I,
Bhatia Mickie
Publication year - 2014
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.15252/embr.201438842
Subject(s) - notch signaling pathway , haematopoiesis , biology , induced pluripotent stem cell , stem cell , signal transduction , bone marrow , hematopoietic stem cell , microbiology and biotechnology , hes3 signaling axis , immunology , cancer research , genetics , embryonic stem cell , gene
The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses on recent developments in understanding the role of Notch signaling in the human hematopoietic system with an emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Based on recent insights, we summarize potential strategies for treatment of human hematological malignancies toward the concept of targeting Notch signaling for fate regulation.