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Sphingosine‐1‐phosphate: The missing link between NOD1/2 and ER stress
Author(s) -
Lu Yan,
Neculai Dante
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108812
Subject(s) - china , library science , biology , history , computer science , archaeology
The cytosolic NOD1 and NOD2 pattern recognition receptors are typically known as sensors of bacterial peptidoglycan fragments. A new study in this issue links NOD1/2 activation with ER homeostasis through the bioactive metabolite sphingosine‐1‐phosphate (S1P).