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ZZ domains keep cytosol to vacuole delivery whiZZing along
Author(s) -
Hama Yutaro,
Zhang Sidi,
Mizushima Noboru
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108777
Subject(s) - vacuole , biology , autophagy , signal transducing adaptor protein , microbiology and biotechnology , cytosol , lysosome , yeast , transport protein , saccharomyces cerevisiae , biochemistry , signal transduction , enzyme , cytoplasm , apoptosis
Selective autophagy relies on adaptor proteins to bind and transport cargos (or substrates) to the lysosome or vacuole, yet the mechanisms for cargo recognition are not well understood. In this issue, Wang et al (2021) showed that in the fission yeast, Nbr1, a homolog of a mammalian selective autophagy adaptor, recognizes vacuolar hydrolases Ams1 and Ape4 through both versatile and cargo‐specific interactions with the Nbr1 ZZ1 domain.