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Prime time for the recycling endosome
Author(s) -
Ceresa Brian P
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108758
Subject(s) - endosome , biology , crosstalk , endocytic cycle , microbiology and biotechnology , phosphorylation , receptor , endocytosis , biochemistry , intracellular , physics , optics
Receptor crosstalk is the phenomenon by which one cell surface receptor communicates with another to modulate its activity. In this issue, Smith et␣al (2021) demonstrate that such crosstalk may involve endocytic trafficking, as ligands promoting FGFR2b recycling induce a specific “priming” EGFR phosphorylation to direct unliganded EGFR to the recycling endosome, slow the lysosomal degradation of ligand‐stimulated EGFR, and enhance signaling and cell proliferation.