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Keep the fate: how chromatin regulators safeguard embryonic stem cell identity
Author(s) -
Janiszewski Adrian,
Georgolopoulos Grigorios,
Balli Martina,
Athanasouli Paraskevi,
Lluis Frederic,
Pasque Vincent
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108437
Subject(s) - biology , chromatin , embryonic stem cell , stem cell , microbiology and biotechnology , safeguard , cell fate determination , genetics , computational biology , transcription factor , dna , gene , law , political science
Segregation of cells that form the embryo from those that produce the surrounding extra‐embryonic tissues is critical for early mammalian development, but the regulatory layers governing these first cell fate decisions remain poorly understood. Recent work in The EMBO Journal identifies two chromatin regulators, Hdac3 and Dax1, that synergistically restrict the developmental potential of mouse embryonic stem cells and act as a lineage barrier to primitive endoderm formation.