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Mycobiota dysbiosis: a new nexus in intestinal tumorigenesis
Author(s) -
Papon Nicolas,
Brown Gordon D,
Gow Neil A R
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108175
Subject(s) - mycobiota , biology , carcinogenesis , dysbiosis , gut flora , colorectal cancer , immunology , cancer research , cancer , microbiology and biotechnology , genetics , ecology
While there is growing evidence that perturbation of the gut microbiota can result in a variety of pathologies including gut tumorigenesis, the influence of commensal fungi remains less clear. In this issue, Zhu et al (2021) show that mycobiota dysbiosis stimulates energy metabolism changes in subepithelial macrophages promoting colon cancer via enhancing innate lymphoid cell activity. These findings provide insights into a role of the gut flora in intestinal carcinogenesis and suggest opportunities for adjunctive antifungal or immunotherapeutic strategies to prevent colorectal cancer.