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GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth
Author(s) -
Palm Wilhelm
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021108070
Subject(s) - biology , sphingolipid , glycosphingolipid , microbiology and biotechnology , biosynthesis , golgi apparatus , function (biology) , biochemistry , cell growth , ceramide , cell , enzyme , apoptosis
Glycosphingolipids are a structurally diverse class of lipids that regulate plasma membrane protein function. Rizzo et al (2021) now show that GOLPH3 promotes intra‐Golgi transport of several enzymes that function at branching points of sphingolipid biosynthesis. By regulating the cellular sphingolipidome, GOLPH3 promotes growth factor signaling and cell proliferation, which may explain its oncogenic properties.