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Halting SARS‐CoV‐2: lung organoids step up to the plate
Author(s) -
Leibel Sandra L,
Sun Xin
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2021107651
Subject(s) - library science , covid-19 , humanities , medicine , art , computer science , pathology , disease , infectious disease (medical specialty)
Defining the pulmonary cell types infected by SARS‐CoV‐2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID‐19. Recent work establishing a human lung organoid‐derived air–liquid interface model permissive to SARS‐CoV‐2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection‐induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.