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Centrosomes: Please keep your social distance!
Author(s) -
Krenning Lenno,
Raaijmakers Jonne A,
Medema René H
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020107525
Subject(s) - centrosome , biology , centrosome cycle , supernumerary , microbiology and biotechnology , appendage , chromosome segregation , genetics , chromosome , cell cycle , cell , anatomy , gene
Accurate control of centrosome number is essential for proper chromosome segregation, and it is well established that centrosome abnormalities can trigger a p53‐dependent cell cycle arrest. Two new studies published in The EMBO Journal demonstrate how PIDD1 is recruited to centrosomes and that the localization of PIDD1 to distal appendages of centrosomes is required for PIDDosome activation at clustered supernumerary centrosomes.