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Membrane protein biogenesis by the EMC
Author(s) -
Alvira Sara,
Corey Robin A,
Collinson Ian,
Römisch Karin
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020107407
Subject(s) - biology , endoplasmic reticulum , microbiology and biotechnology , biogenesis , transmembrane protein , membrane protein , organelle biogenesis , protein targeting , biophysics , computational biology , membrane , genetics , gene , receptor
The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.