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Immune subversion by HIV: part B
Author(s) -
Vanpouille Christophe,
Margolis Leonid
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020107167
Subject(s) - human immunodeficiency virus (hiv) , subversion , library science , human development (humanity) , medicine , family medicine , political science , law , politics , computer science
While HIV‐1 infects T but not B cells, it nevertheless impairs the function of B cells and thereby contribute to the failure to produce neutralizing antibodies. In this issue, Kaw et al describe the mechanisms leading to this failure and report a key role for the HIV‐1 protein NEF in preventing B‐cell maturation into antibody‐producing plasma cells.