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FXR proteins bring new perspectives to nucleoporins' homeostasis
Author(s) -
Holzer Guillaume,
Antonin Wolfram
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020106510
Subject(s) - nucleoporin , biology , nuclear pore , ribonucleoprotein , microbiology and biotechnology , translation (biology) , cytoplasm , heterogeneous nuclear ribonucleoprotein , transport protein , rna binding protein , nuclear protein , nuclear transport , cell nucleus , genetics , rna , gene , transcription factor , messenger rna
FXR proteins are part of ribonucleoprotein granules controlling stability, translation, and cellular localization of target mRNA s. In the current issue, Agote‐Aran et al extend the repertoire of FXR protein action and show that they are also involved in the transport of nuclear pore complex components to the nuclear envelope and thereby prevent cytoplasmic aggregation of these proteins.