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A hairy tale: SIRT 7 safeguards skin stem cells during aging
Author(s) -
Simon Matthew,
Emmrich Stephan,
Seluanov Andrei,
Gorbunova Vera
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020106294
Subject(s) - biology , stem cell , microbiology and biotechnology , skin aging , cancer research , medicine , dermatology
Stem cell regulation during both normal development and aging has become one of the fastest growing topics in biology. Here, new work by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and highlights how SIRT 7, a member of the sirtuin family of protein deacylases and mono‐ ADP ribosylases, protects adult hair follicle stem cells from aging by ensuring their hair cycle progression.