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Transcytosis in the development and morphogenesis of epithelial tissues
Author(s) -
Serra Nicholas D,
Sundaram Meera V
Publication year - 2021
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020106163
Subject(s) - transcytosis , microbiology and biotechnology , biology , cytoplasm , morphogenesis , vesicle , extracellular , cell membrane , endocytosis , transport protein , cell signaling , cell , membrane , signal transduction , biochemistry , gene
Transcytosis is a form of specialized transport through which an extracellular cargo is endocytosed, shuttled across the cytoplasm in membrane‐bound vesicles, and secreted at a different plasma membrane surface. This important process allows membrane‐impermeable macromolecules to pass through a cell and become accessible to adjacent cells and tissue compartments. Transcytosis also promotes redistribution of plasma membrane proteins and lipids to different regions of the cell surface. Here we review transcytosis and highlight in vivo studies showing how developing epithelial cells use it to change shape, to migrate, and to relocalize signaling molecules.