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Selective autophagy bears bone
Author(s) -
Fraiberg Milana,
Elazar Zvulun
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020105965
Subject(s) - biology , autophagy , computational biology , microbiology and biotechnology , genetics , apoptosis
The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER‐phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER‐phagy through a TFEB/TFE‐dependent transcriptional regulation of the ER‐phagy receptor Fam134b, a process essential for bone ossification and skeletal development.