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Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast
Author(s) -
Peet Graham,
Bennett F Chris,
Bennett Mariko L
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020105924
Subject(s) - biology , microglia , phosphatidylserine , neuroscience , microbiology and biotechnology , genetics , immunology , inflammation , phospholipid , membrane
Microglia, the brain's tissue‐resident macrophages, contribute to the developmental elimination of extranumerary synapses and to pathologic synapse loss in mouse models of neurodegeneration. Two papers published in The EMBO Journal reveal that phosphatidylserine ( PS ) is a neuronal cue for microglial synapse elimination.