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CCR 5 deficiency/ CCR 5Δ32: resistant to HIV infection at the cost of curtailed CD 4 + T cell memory responses
Author(s) -
Matti Christoph,
Legler Daniel F
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020105854
Subject(s) - biology , human immunodeficiency virus (hiv) , immunology , virology
Orchestrated trafficking and activation by pathogen‐derived peptides define the ability of CD 4 + T helper cells to contribute to an effective adaptive immunity. In this issue of The EMBO Journal , Martín‐Leal et al show that the inflammatory chemokine receptor CCR 5, well known for its role in cell migration and HIV infection, regulates ceramide synthesis and TCR nanoclustering to promote memory CD 4 + T cell activation.