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Extracellular vesicles: eat glutamine and spit acidic bubbles
Author(s) -
Niel Guillaume,
Théry Clotilde
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020105119
Subject(s) - biology , glutamine , vesicle , extracellular vesicles , extracellular , biochemistry , biophysics , microbiology and biotechnology , amino acid , membrane
Extracellular vesicles mediate transfer of diverse molecular content to target cells in order to induce phenotypic changes, which has put them under the spotlight as likely major players in cell‐to‐cell communication. However, extracellular vesicle heterogeneity in terms of intracellular origin has only recently been recognized as a potential determinant of their activity. Recent work by Fan et al (2020) illustrates how lack of external resources that affect cellular homeostasis and signaling can also modulate EV biogenesis, by inducing the production of a novel subpopulation of exosomes enriched in Rab11a with context‐dependent roles in Drosophila gland physiology and cancer cell aggressiveness.