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Chloride accumulation in endosomes and lysosomes: facts checked in mice
Author(s) -
Schwappach Blanche
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020104812
Subject(s) - endosome , biology , microbiology and biotechnology , chloride , intracellular , materials science , metallurgy
Loss of the ClC‐3 chloride/proton exchanger found in intracellular compartments leads to marked neurodegeneration. New genetic work by Weinert et al (2020) now shows that selective impairment of ClC‐3's ion exchange activity is sufficient to elicit this severe phenotype in vivo . ClC‐3 cooperates with the closely related ClC‐4 in protecting endolysosomal chloride balance and neuronal integrity.