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Blocking the road to de‐differentiation: HNF 1A/ KDM 6A complex safeguards epithelial integrity in pancreatic cancer
Author(s) -
Bärthel Stefanie,
Schneider Günter,
Saur Dieter
Publication year - 2020
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2020104759
Subject(s) - german , cancer , medicine , library science , computer science , history , archaeology
Epithelial differentiation of normal and tumor cells is orchestrated by lineage‐determining transcriptional regulatory networks that enforce cell identity. Recent research by Kalisz et al (2020) in the EMBO Journal elucidates the molecular mechanisms by which a transcriptional differentiation program governed by HNF 1A and KDM 6A maintains acinar differentiation and the epithelial identity of pancreatic ductal adenocarcinoma ( PDAC ). Loss of function of either transcriptional regulator induces tumor progression to a poorly differentiated and highly aggressive PDAC subtype with a squamous transcriptome and poor prognosis.