Geranylgeranyl generosity: a new prenyl‐transferase gives a fat to a SNARE protein

Protein prenylation, a well‐defined protein consensus motifs direct modification by one of three prenyl‐transferases, has been an area of fairly settled science for 20 or 30 years. Protein prenylation, the specific prenyl modification (farnesyl or geranylgeranyl), as well as the prenyl‐transferases involved can be inferred by protein sequence. Two new papers now upset this settled wisdom with the discovery of a fourth prenyl‐transferase, namely geranylgeranyl‐transferase‐ III ( GGT ase‐ III ) (Kuchay et al , 2019; Shirakawa et al , 2020).