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Shugoshin 2—a new guardian for heat shock transcription
Author(s) -
Kainth Amoldeep S,
Meduri Rajyalakshmi,
Pandit Vickky,
Rubio Linda S,
Gross David S
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019104077
Subject(s) - library science , biology , computer science
Takii et al (2019) demonstrate in a recent issue of The EMBO Journal that the pericentromeric protein, SGO 2, serves as a novel transcriptional coactivator of HSF 1, contributing to PIC assembly and expression of Heat Shock Protein ( HSP ) genes. This finding highlights repurposing of a protein with a nuclear function to drive transcription of proteotoxic stress machinery genes.