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A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells
Author(s) -
Evano Brendan,
Tajbakhsh Shahragim
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019103924
Subject(s) - biology , niche , stem cell niche , stem cell , zoology , microbiology and biotechnology , ecology , progenitor cell
Ageing is a multi‐factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal , Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche‐derived granulocyte colony‐stimulating factor (G‐ CSF ).