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More or less – the same? mRNA fluctuations are balanced during translation
Author(s) -
Kozlovski Itamar,
Agami Reuven
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019103651
Subject(s) - biology , translation (biology) , messenger rna , microbiology and biotechnology , genetics , gene
Transcription factors have been traditionally studied at the level of transcription, neglecting a potential impact on protein translation. A new study published by Lorent et al (2019) describes a mechanism by which fluctuations in mRNA abundance are counteracted during translation upon estrogen receptor‐alpha ( ER α) depletion. This phenomenon, termed translational offsetting, is prevalent and programmed to maintain essential proteins at constant levels.