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53BP1—DNA repair enters a new liquid phase
Author(s) -
Piccinno Rossana,
Minneker Vera,
Roukos Vassilis
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019102871
Subject(s) - biology , dna , dna repair , genetics , phase (matter) , computational biology , microbiology and biotechnology , physics , quantum mechanics
In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal , Kilic et al show that DNA repair focal assemblies marked by accumulation of 53 BP 1 are phase separated liquid compartments. This liquid droplet‐like behavior of 53 BP 1 compartments might help to coordinate local lesion recognition with global gene activation in response to DNA damage.