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Antigen cross‐presentation: proteasome location, location, location
Author(s) -
Desjardins Michel
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019102799
Subject(s) - biology , antigen , proteasome , antigen presentation , cross presentation , computational biology , presentation (obstetrics) , microbiology and biotechnology , genetics , major histocompatibility complex , immune system , t cell , mhc class i , medicine , radiology
Our understanding of the mechanisms by which peptides from proteins present in phagosomes and endosomes are processed and presented on MHC class I molecules, in a pathway called cross‐presentation, is still incomplete. One of the main questions arising from currently proposed models is how do proteins in the phagosome lumen reach the proteasome in the cytoplasm to be processed properly. In this issue of The EMBO Journal , Sengupta et al (2019) present evidence for a surprising turn of events where, in fact, the proteasome acts within the lumen of endosomes and phagosomes.