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EGAD ! There is an ERAD doppelganger in the Golgi
Author(s) -
Fonseca Daniel,
Carvalho Pedro
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019102679
Subject(s) - golgi apparatus , endoplasmic reticulum , endoplasmic reticulum associated protein degradation , endosome , microbiology and biotechnology , chemistry , biology , unfolded protein response , intracellular
Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitated by ESCRT ‐dependent lysosomal degradation. In this issue of The EMBO Journal , Schmidt et al define a previously uncharacterized endosome and Golgi‐associated degradation ( EGAD ) pathway. This pathway, which has remarkable similarities to ERAD in the endoplasmic reticulum, operates in post‐ ER organelles via the proteasome and contributes to lipid homeostasis in eukaryotic cells.