Premium
Of seeds and supplements: structural insights into extended micro RNA –target pairing
Author(s) -
Fabian Marc R
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019102477
Subject(s) - microrna , argonaute , biology , library science , rna , gene silencing , rna interference , genetics , computer science , gene
Metazoan micro(mi) RNA s guide Argonaute proteins to their targets via perfect pairing to the seed region, located near the 5′ end of the mi RNA . In this issue of The EMBO Journal , Sheu‐Gruttadauria et al report the crystal structure of human Argonaute 2 in complex with both a mi RNA and target RNA and show that mi RNA 3′ supplementary nucleotides can increase target affinity and may contribute more to mi RNA ‐mediated silencing than is currently appreciated.