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Chopping GSDMD : caspase‐8 has joined the team of pyroptosis‐mediating caspases
Author(s) -
Gram Anna M,
Booty Lee M,
Bryant Clare E
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019102065
Subject(s) - biology , pyroptosis , caspase , microbiology and biotechnology , apoptosis , biochemistry , programmed cell death
Inflammatory and apoptotic caspases mediate two distinct forms of cell death: pyroptosis and apoptosis, respectively. Three independent studies have now demonstrated that the “apoptotic” caspase‐8 can cleave gasdermin D ( GSDMD ) leading to pyroptosis‐like cell death and IL ‐1β release in murine macrophages (Orning et al , 2018; Sarhan et al , 2018; Chen et al , 2019). Orning et al and Chen/Demarco et al also show that the NLRP 3 inflammasome is activated downstream of active caspase‐8, but they attribute this inflammasome activation to different pore‐forming proteins, GSDMD and pannexin‐1, respectively (Orning et al , 2018; Chen et al , 2019).