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A choreography of intracellular Ca 2+ and extracellular ATP to refine auditory nociceptors before hearing
Author(s) -
Leitner Michael G,
Oliver Dominik
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019101980
Subject(s) - marburg virus , neuroscience , physiology , medicine , biology , pathology , disease , ebola virus
Our hearing ability is exquisite in terms of sensitivity, dynamic range, and frequency discrimination. However, this acuity comes at the price of high vulnerability to a range of adverse influences—including sustained loud sounds. One may therefore expect that the ear is equipped with an alert system that can help prevent hearing damage, akin to the nociceptive sensory system that safeguards us from undergoing tissue injury. Here, Ceriani et al reveal a complex signaling interplay of sensory and non‐sensory cells that helps setting up such a system in development.